DM is the leading cause of blindness in adults aged 20 to 74 years and end-stage renal disease (ESRD) and a main cause of cardiovascular events. Type 2 DM, characterized by insulin resistance and a relative lack of insulin secretion, accounts for as much as 90% of all cases of DM and its prevalence is increasing. Introductionĭiabetes mellitus (DM) is one of the most common endocrine disorders characterized by hyperglycemia. improves glycemic control by increasing insulin level and reduces TG serum level in type 2 diabetic adult patients. Daily consumption of the fruit extract of Cornus mas L. After 6 weeks of intervention, significant increase in insulin level (1.13 ± 1.90 versus −0.643 ± 1.82, ) as well as decrease in (−0.24 ± 0.429 versus 0.023 ± 0.225, ) and TG (−23.66 ± 55.40 versus 2.83 ± 15.71, ) levels was observed in drug group compared to placebo. Fasting plasma levels of glucose, insulin,, and triglyceride as well as 2-hour postprandial glucose level (2Hpp) were measured before and after the intervention and finally the mean values were compared between groups. Each drug capsule contained 150 mg of anthocyanins. Sixty patients with type 2 diabetes were randomly assigned to two groups to receive either the extract or placebo capsules (2 capsules twice daily) for 6 weeks. In this study, we evaluated the effects of the fruit extract of this plant on biomarkers of glycemic control in adult patients with type 2 diabetes. (cornelian cherry) is traditionally used as an antidiabetic supplement however, there is no related clinical trial.
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